I'm using Screen a lot these days. It's something that I used to use at Aber all those years ago to create virtual tty's when we only had a single screen to use. These days I use it to "background" my sessions so that things can run in the background and I can easily re-connect to my session at a later date.

I've recently switched from using the bitchx irc client to using irssi. I've found a great resource for using screen and irssi together. The hilight window is really good when you've got many connections open.

Here's the guide: A Guide to Efficiently Using Irssi and Screen